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What clinical trials show Across many human randomized trials and meta-analyses up through 2024, silymarin produces a reproducible pattern of improvements in ALT and AST compared with placebo or usual care in a variety of liver conditions

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Primarily, hypothyroidism itself adversely affects gastrointestinal physiology by diminishing gastric mucosal integrity and reducing gastric acid secretion, thereby impairing the efficient absorption of nutrients and trace elements critical for thyroid function, such as selenium, iodine, iron, zinc, and vitamin D (Shulhai et al., 2024)

The slides were rinsed and analyzed after mounting coverglass